منابع مشابه
Which dose of steroids and which cytotoxics for severe lupus?
There have been a number of major advances in the treatment of systemic lupus erythematosus and we are now in the era of biologic therapies for this multisystem autoimmune disorder. There has been a greater awareness of the toxicities of the traditional therapies including the recognition that the doses of corticosteroids used in the past have been excessive, resulting in unacceptable toxicitie...
متن کاملNeurobrucellosis in systemic lupus erythematosus
Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...
متن کاملThe Steroids In the Maintenance of remission of Proliferative Lupus nephritis (SIMPL) pilot trial
BACKGROUND Patients with proliferative lupus nephritis are at risk of frequent relapses. Whether low- dose prednisone prevents relapses is uncertain. OBJECTIVES We undertook a pilot RCT to determine the feasibility of a larger trial. DESIGN Pilot randomized controlled trial. SETTING Single center Canadian outpatient nephrology clinic. PATIENTS Participants with systemic lupus erythemato...
متن کاملPulse dose steroids in severe pulmonary arterial hypertension secondary to systemic lupus erythematosus
OBJECTIVE The pulmonary vascular targeted treatment for systemic lupus erythematosus-associated pulmonary arterial hypertension is similar to other connective tissue disease-associated pulmonary arterial hypertension. In addition, there also appears to be a role for immunosuppression in the overall management. However, the optimal immunosuppressive regimen and what patients will respond to trea...
متن کاملRituximab is an effective treatment for lupus nephritis and allows a reduction in maintenance steroids.
BACKGROUND Lupus nephritis is a life-threatening complication of SLE. Treatment regimes include steroids and cyclophosphamide, both associated with significant morbidity. Newer regimes include mycophenolate mofetil (MMF). We report our outcomes in a prospectively monitored cohort of patients receiving our new standard treatment protocol, comprising rituximab induction therapy and MMF maintenanc...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2010
ISSN: 1945-3477
DOI: 10.1038/scibx.2010.784